Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin

Olawale Folorunso Akinyele; Temitope Oluwatola Akinnusi; Temitope Adekunle Ajayeoba; Ayowole Olaolu Ayeni; Lateefah Moyosore Durosinmi

doi:doi:10.11648/j.sjc.20190703.13

Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin

Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi

Published in Science Journal of Chemistry (Volume 7, Issue 3)

Received: 12 June 2019 Accepted: 23 July 2019 Published: 17 September 2019

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Abstract

Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.

Published in	Science Journal of Chemistry (Volume 7, Issue 3)
DOI	10.11648/j.sjc.20190703.13
Page(s)	67-71
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Antimicrobial, Aroylhydrazone (HL), Aspirin (HASA), Carboxylate, Azomethine

References

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APA Style

Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. (2019). Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Science Journal of Chemistry, 7(3), 67-71. https://doi.org/10.11648/j.sjc.20190703.13

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ACS Style

Olawale Folorunso Akinyele; Temitope Oluwatola Akinnusi; Temitope Adekunle Ajayeoba; Ayowole Olaolu Ayeni; Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci. J. Chem. 2019, 7(3), 67-71. doi: 10.11648/j.sjc.20190703.13

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AMA Style

Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci J Chem. 2019;7(3):67-71. doi: 10.11648/j.sjc.20190703.13

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@article{10.11648/j.sjc.20190703.13,
  author = {Olawale Folorunso Akinyele and Temitope Oluwatola Akinnusi and Temitope Adekunle Ajayeoba and Ayowole Olaolu Ayeni and Lateefah Moyosore Durosinmi},
  title = {Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {3},
  pages = {67-71},
  doi = {10.11648/j.sjc.20190703.13},
  url = {https://doi.org/10.11648/j.sjc.20190703.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190703.13},
  abstract = {Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.},
 year = {2019}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin
AU  - Olawale Folorunso Akinyele
AU  - Temitope Oluwatola Akinnusi
AU  - Temitope Adekunle Ajayeoba
AU  - Ayowole Olaolu Ayeni
AU  - Lateefah Moyosore Durosinmi
Y1  - 2019/09/17
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190703.13
DO  - 10.11648/j.sjc.20190703.13
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 67
EP  - 71
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190703.13
AB  - Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
VL  - 7
IS  - 3
ER  -

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Author Information

Olawale Folorunso Akinyele

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Oluwatola Akinnusi

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Adekunle Ajayeoba

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Ayowole Olaolu Ayeni

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Lateefah Moyosore Durosinmi

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

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APA Style

Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. (2019). Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Science Journal of Chemistry, 7(3), 67-71. https://doi.org/10.11648/j.sjc.20190703.13

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ACS Style

Olawale Folorunso Akinyele; Temitope Oluwatola Akinnusi; Temitope Adekunle Ajayeoba; Ayowole Olaolu Ayeni; Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci. J. Chem. 2019, 7(3), 67-71. doi: 10.11648/j.sjc.20190703.13

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AMA Style

Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi. Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin. Sci J Chem. 2019;7(3):67-71. doi: 10.11648/j.sjc.20190703.13

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@article{10.11648/j.sjc.20190703.13,
  author = {Olawale Folorunso Akinyele and Temitope Oluwatola Akinnusi and Temitope Adekunle Ajayeoba and Ayowole Olaolu Ayeni and Lateefah Moyosore Durosinmi},
  title = {Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {3},
  pages = {67-71},
  doi = {10.11648/j.sjc.20190703.13},
  url = {https://doi.org/10.11648/j.sjc.20190703.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190703.13},
  abstract = {Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.},
 year = {2019}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin
AU  - Olawale Folorunso Akinyele
AU  - Temitope Oluwatola Akinnusi
AU  - Temitope Adekunle Ajayeoba
AU  - Ayowole Olaolu Ayeni
AU  - Lateefah Moyosore Durosinmi
Y1  - 2019/09/17
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190703.13
DO  - 10.11648/j.sjc.20190703.13
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 67
EP  - 71
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190703.13
AB  - Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
VL  - 7
IS  - 3
ER  -

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