Synthesis, Characterization and <i>In Vitro</i> Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands

Quang Trung Nguyen; Quang Hai Lam; Phuong Nam Pham Thi; Van Tuyen Nguyen

doi:doi:10.11648/j.sjc.20190702.13

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Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands

Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen

Published in Science Journal of Chemistry (Volume 7, Issue 2)

Received: 15 May 2019 Accepted: 17 June 2019 Published: 1 July 2019

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Abstract

A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC₅₀ 1.92 µM.

Published in	Science Journal of Chemistry (Volume 7, Issue 2)
DOI	10.11648/j.sjc.20190702.13
Page(s)	49-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Salicylaldiminato Pt (II) Complexes, Synthesis, Photophysical Properties, Cytotoxicity

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APA Style

Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. (2019). Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Science Journal of Chemistry, 7(2), 49-55. https://doi.org/10.11648/j.sjc.20190702.13

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ACS Style

Quang Trung Nguyen; Quang Hai Lam; Phuong Nam Pham Thi; Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci. J. Chem. 2019, 7(2), 49-55. doi: 10.11648/j.sjc.20190702.13

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AMA Style

Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci J Chem. 2019;7(2):49-55. doi: 10.11648/j.sjc.20190702.13

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@article{10.11648/j.sjc.20190702.13,
  author = {Quang Trung Nguyen and Quang Hai Lam and Phuong Nam Pham Thi and Van Tuyen Nguyen},
  title = {Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {2},
  pages = {49-55},
  doi = {10.11648/j.sjc.20190702.13},
  url = {https://doi.org/10.11648/j.sjc.20190702.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190702.13},
  abstract = {A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.},
 year = {2019}
}

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TY  - JOUR
T1  - Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands
AU  - Quang Trung Nguyen
AU  - Quang Hai Lam
AU  - Phuong Nam Pham Thi
AU  - Van Tuyen Nguyen
Y1  - 2019/07/01
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190702.13
DO  - 10.11648/j.sjc.20190702.13
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 49
EP  - 55
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190702.13
AB  - A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.
VL  - 7
IS  - 2
ER  -

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Author Information

Quang Trung Nguyen

Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Quang Hai Lam

Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Phuong Nam Pham Thi

Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Van Tuyen Nguyen

Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

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Plain Text BibTeX RIS

APA Style

Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. (2019). Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Science Journal of Chemistry, 7(2), 49-55. https://doi.org/10.11648/j.sjc.20190702.13

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ACS Style

Quang Trung Nguyen; Quang Hai Lam; Phuong Nam Pham Thi; Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci. J. Chem. 2019, 7(2), 49-55. doi: 10.11648/j.sjc.20190702.13

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AMA Style

Quang Trung Nguyen, Quang Hai Lam, Phuong Nam Pham Thi, Van Tuyen Nguyen. Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands. Sci J Chem. 2019;7(2):49-55. doi: 10.11648/j.sjc.20190702.13

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@article{10.11648/j.sjc.20190702.13,
  author = {Quang Trung Nguyen and Quang Hai Lam and Phuong Nam Pham Thi and Van Tuyen Nguyen},
  title = {Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {2},
  pages = {49-55},
  doi = {10.11648/j.sjc.20190702.13},
  url = {https://doi.org/10.11648/j.sjc.20190702.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190702.13},
  abstract = {A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Characterization and In Vitro Cytotoxicity of Platinum (II) Complexes with Some Tetradentate Salen Ligands
AU  - Quang Trung Nguyen
AU  - Quang Hai Lam
AU  - Phuong Nam Pham Thi
AU  - Van Tuyen Nguyen
Y1  - 2019/07/01
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190702.13
DO  - 10.11648/j.sjc.20190702.13
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 49
EP  - 55
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190702.13
AB  - A series of platinum (II) complexes of Schiff bases derived from various salicylaldehydes with ethylenediamine were synthesized and characterized by ESI-MS, NMR and IR. The results of ESI-MS and NMR spectra data showed that the separation of hydrogen from hydoxy group and different chemical shifts of typical bondings between ligands and platinum (II) complexes evidenced for coordination of Pt (II) and tetradentate ligands. The IR spectral studies indicated the binding sites of the salen ligands with Pt (II). Their photophysical properties studied by UV-vis and luminescent spectroscopies performed the photoactivity of investigated platinum (II) complexes. The obvious effect of electron-withdrawing and – donoring substituted groups at the same position of salicyl rings and the impact of methoxy at different position of salicyl rings to their photophysical properties were studied and compared to complex 1 without substituted group. The obtained complexes were screened for their in vitro antitumour activities against KB and MCF-7 human cancer cell lines. Complex 4 showed the best bioactivity for both KB and MCF-7 human cancer cells with IC50 1.92 µM.
VL  - 7
IS  - 2
ER  -

Copy | Download