The present study was designed to determine the levels of C-reactive protein and creatine kinase-MM in Nigerian naïve (stage 2) HIV seropositive subjects co-infected with Plasmodium falciparum. A total of 204 subjects (aged between 18 and 45 years) were randomly studied. Among these were 74 naïve (stage 2) HIV seropositive subjects (confirmed by Western blot method), 70 naïve (stage 2) HIV seropositive subjects co-infected with P. falciparum (confirmed by Western blot and microscopic methods respectively) and 60 apparently healthy individuals (confirmed to be negative for Human immunodeficiency virus and P. falciparum by Western blot and microscopic methods respectively). Absolute lymphocyte counts was estimated using Sysmex® Automated Hematology Analyzer, whereas CD4+ cell count was estimated using Partec® Cyflow Counter. C-reactive protein and creatine kinase was estimated using enzyme-linked immunosorbent assay methods. The creatine kinase-MM and C-reactive protein concentrations were significantly higher in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000) respectively. Whereas the absolute lymphocyte counts and CD4+ T cell counts were significantly lower in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000). The increased expression of C- reactive protein and creatine kinase-MM coupled with the decrease in absolute lymphocyte and CD4+ cell counts significantly contributes to the pathogenesis of HIV and P. falciparum infections.
| Published in | International Journal of Immunology (Volume 5, Issue 2) |
| DOI | 10.11648/j.iji.20170502.12 |
| Page(s) | 37-40 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
C - reactive Protein, Creatine Kinase-MM, Human Immunodeficiency Virus, Stage 2, Plasmodium falciparum
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APA Style
Digban Kester, Ehiaghe Friday Alfred. (2017). The Levels of Serum C - reactive protein and Creatine Kinase-MM in Human Immunodeficiency Virus Seropositive Subjects Co-infected with Plasmodium falciparum. International Journal of Immunology, 5(2), 37-40. https://doi.org/10.11648/j.iji.20170502.12
ACS Style
Digban Kester; Ehiaghe Friday Alfred. The Levels of Serum C - reactive protein and Creatine Kinase-MM in Human Immunodeficiency Virus Seropositive Subjects Co-infected with Plasmodium falciparum. Int. J. Immunol. 2017, 5(2), 37-40. doi: 10.11648/j.iji.20170502.12
AMA Style
Digban Kester, Ehiaghe Friday Alfred. The Levels of Serum C - reactive protein and Creatine Kinase-MM in Human Immunodeficiency Virus Seropositive Subjects Co-infected with Plasmodium falciparum. Int J Immunol. 2017;5(2):37-40. doi: 10.11648/j.iji.20170502.12
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Download@article{10.11648/j.iji.20170502.12,
author = {Digban Kester and Ehiaghe Friday Alfred},
title = {The Levels of Serum C - reactive protein and Creatine Kinase-MM in Human Immunodeficiency Virus Seropositive Subjects Co-infected with Plasmodium falciparum},
journal = {International Journal of Immunology},
volume = {5},
number = {2},
pages = {37-40},
doi = {10.11648/j.iji.20170502.12},
url = {https://doi.org/10.11648/j.iji.20170502.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20170502.12},
abstract = {The present study was designed to determine the levels of C-reactive protein and creatine kinase-MM in Nigerian naïve (stage 2) HIV seropositive subjects co-infected with Plasmodium falciparum. A total of 204 subjects (aged between 18 and 45 years) were randomly studied. Among these were 74 naïve (stage 2) HIV seropositive subjects (confirmed by Western blot method), 70 naïve (stage 2) HIV seropositive subjects co-infected with P. falciparum (confirmed by Western blot and microscopic methods respectively) and 60 apparently healthy individuals (confirmed to be negative for Human immunodeficiency virus and P. falciparum by Western blot and microscopic methods respectively). Absolute lymphocyte counts was estimated using Sysmex® Automated Hematology Analyzer, whereas CD4+ cell count was estimated using Partec® Cyflow Counter. C-reactive protein and creatine kinase was estimated using enzyme-linked immunosorbent assay methods. The creatine kinase-MM and C-reactive protein concentrations were significantly higher in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000) respectively. Whereas the absolute lymphocyte counts and CD4+ T cell counts were significantly lower in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000). The increased expression of C- reactive protein and creatine kinase-MM coupled with the decrease in absolute lymphocyte and CD4+ cell counts significantly contributes to the pathogenesis of HIV and P. falciparum infections.},
year = {2017}
}
TY - JOUR T1 - The Levels of Serum C - reactive protein and Creatine Kinase-MM in Human Immunodeficiency Virus Seropositive Subjects Co-infected with Plasmodium falciparum AU - Digban Kester AU - Ehiaghe Friday Alfred Y1 - 2017/04/14 PY - 2017 N1 - https://doi.org/10.11648/j.iji.20170502.12 DO - 10.11648/j.iji.20170502.12 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 37 EP - 40 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20170502.12 AB - The present study was designed to determine the levels of C-reactive protein and creatine kinase-MM in Nigerian naïve (stage 2) HIV seropositive subjects co-infected with Plasmodium falciparum. A total of 204 subjects (aged between 18 and 45 years) were randomly studied. Among these were 74 naïve (stage 2) HIV seropositive subjects (confirmed by Western blot method), 70 naïve (stage 2) HIV seropositive subjects co-infected with P. falciparum (confirmed by Western blot and microscopic methods respectively) and 60 apparently healthy individuals (confirmed to be negative for Human immunodeficiency virus and P. falciparum by Western blot and microscopic methods respectively). Absolute lymphocyte counts was estimated using Sysmex® Automated Hematology Analyzer, whereas CD4+ cell count was estimated using Partec® Cyflow Counter. C-reactive protein and creatine kinase was estimated using enzyme-linked immunosorbent assay methods. The creatine kinase-MM and C-reactive protein concentrations were significantly higher in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000) respectively. Whereas the absolute lymphocyte counts and CD4+ T cell counts were significantly lower in HIV seropositive subjects co-infected with malaria when compared with the controls subjects (P = 0.000). The increased expression of C- reactive protein and creatine kinase-MM coupled with the decrease in absolute lymphocyte and CD4+ cell counts significantly contributes to the pathogenesis of HIV and P. falciparum infections. VL - 5 IS - 2 ER -
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