Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients

Mustafa Yıldırım; Arsenal Sezgin; Utku Dönem Dilli; Dinc Süren; Mustafa Yıldız; Vildan Kaya; Cem Sezer; Nurullah Bülbüller

doi:doi:10.11648/j.crj.20130102.12

Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients

Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, Vildan Kaya, Cem Sezer, Nurullah Bülbüller

Published in Cancer Research Journal (Volume 1, Issue 2)

Received: 20 June 2013 Published: 10 August 2013

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Abstract

Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected, and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.

Published in	Cancer Research Journal (Volume 1, Issue 2)
DOI	10.11648/j.crj.20130102.12
Page(s)	20-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Gastric cancer, Prognosis, HER 2, Chemotherapy, Docetaxel, Cisplatin

References

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APA Style

Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. (2013). Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Research Journal, 1(2), 20-25. https://doi.org/10.11648/j.crj.20130102.12

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ACS Style

Mustafa Yıldırım; Arsenal Sezgin; Utku Dönem Dilli; Dinc Süren; Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res. J. 2013, 1(2), 20-25. doi: 10.11648/j.crj.20130102.12

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AMA Style

Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res J. 2013;1(2):20-25. doi: 10.11648/j.crj.20130102.12

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@article{10.11648/j.crj.20130102.12,
  author = {Mustafa Yıldırım and Arsenal Sezgin and Utku Dönem Dilli and Dinc Süren and Mustafa Yıldız and Vildan Kaya and Cem Sezer and Nurullah Bülbüller},
  title = {Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.crj.20130102.12},
  url = {https://doi.org/10.11648/j.crj.20130102.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130102.12},
  abstract = {Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.},
 year = {2013}
}

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TY  - JOUR
T1  - Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients
AU  - Mustafa Yıldırım
AU  - Arsenal Sezgin
AU  - Utku Dönem Dilli
AU  - Dinc Süren
AU  - Mustafa Yıldız
AU  - Vildan Kaya
AU  - Cem Sezer
AU  - Nurullah Bülbüller
Y1  - 2013/08/10
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130102.12
DO  - 10.11648/j.crj.20130102.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130102.12
AB  - Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.
VL  - 1
IS  - 2
ER  -

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Author Information

Mustafa Yıldırım
Arsenal Sezgin

Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey
Utku Dönem Dilli
Dinc Süren

Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey
Mustafa Yıldız
Vildan Kaya

Süleyman Demirel University School of Medicine, Department of Radiation Oncology, Isparta, Turkey
Cem Sezer

Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey
Nurullah Bülbüller

Antalya Education and Research Hospital, Department of General Surgery, Antalya, Turkey

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APA Style

Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. (2013). Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Research Journal, 1(2), 20-25. https://doi.org/10.11648/j.crj.20130102.12

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ACS Style

Mustafa Yıldırım; Arsenal Sezgin; Utku Dönem Dilli; Dinc Süren; Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res. J. 2013, 1(2), 20-25. doi: 10.11648/j.crj.20130102.12

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AMA Style

Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res J. 2013;1(2):20-25. doi: 10.11648/j.crj.20130102.12

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@article{10.11648/j.crj.20130102.12,
  author = {Mustafa Yıldırım and Arsenal Sezgin and Utku Dönem Dilli and Dinc Süren and Mustafa Yıldız and Vildan Kaya and Cem Sezer and Nurullah Bülbüller},
  title = {Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.crj.20130102.12},
  url = {https://doi.org/10.11648/j.crj.20130102.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130102.12},
  abstract = {Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.},
 year = {2013}
}

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TY  - JOUR
T1  - Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients
AU  - Mustafa Yıldırım
AU  - Arsenal Sezgin
AU  - Utku Dönem Dilli
AU  - Dinc Süren
AU  - Mustafa Yıldız
AU  - Vildan Kaya
AU  - Cem Sezer
AU  - Nurullah Bülbüller
Y1  - 2013/08/10
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130102.12
DO  - 10.11648/j.crj.20130102.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130102.12
AB  - Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.
VL  - 1
IS  - 2
ER  -

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