Background: The effect of capsaicin (the active ingredient in Capsicum frutescensLinn. [Solanaceae] on coagulationwas reported in several studies. Current research is being directed at elucidating if capsaicin has any effect on coagulation. Objectives: To investigate if either the ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) or capsaicin (FlukaBiotechnika-CPF) on coagulation. Methodss: The effects of ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) and capsaicin (FlukaBiotechnika-CPF) was examined on rat hind paw Ten animals in each of three treatment groups received 2.5, 5.0, 10 mg/kg (i.p.) capsaicin respectively. Data obtained were pooled and analysed using repeated ANOVA, in a general linear model with the CPSS software. Results: Compared to the control group, the mean INR was statistically significant (P<0.05). Conclusion: Taken together, the use of capsaicin at therapeutic doses (2.5-10.0 mg/kg) may reduce thromboembolism without any clinically relevant alteration in platelets.
| Published in | Clinical Medicine Research (Volume 3, Issue 5) |
| DOI | 10.11648/j.cmr.20140305.17 |
| Page(s) | 145-149 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Capsicum Frutescens, ‘Chili’, Ethylacetate Extract, Capsaicin, Coagulation
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APA Style
Jolayemi Adebayo Taiwo Ezekiel, Ojewole John Akanni Oluwole. (2014). Effects of Capsaicin on Coagulation: Will this be the New Blood Thinner. Clinical Medicine Research, 3(5), 145-149. https://doi.org/10.11648/j.cmr.20140305.17
ACS Style
Jolayemi Adebayo Taiwo Ezekiel; Ojewole John Akanni Oluwole. Effects of Capsaicin on Coagulation: Will this be the New Blood Thinner. Clin. Med. Res. 2014, 3(5), 145-149. doi: 10.11648/j.cmr.20140305.17
AMA Style
Jolayemi Adebayo Taiwo Ezekiel, Ojewole John Akanni Oluwole. Effects of Capsaicin on Coagulation: Will this be the New Blood Thinner. Clin Med Res. 2014;3(5):145-149. doi: 10.11648/j.cmr.20140305.17
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Download@article{10.11648/j.cmr.20140305.17,
author = {Jolayemi Adebayo Taiwo Ezekiel and Ojewole John Akanni Oluwole},
title = {Effects of Capsaicin on Coagulation: Will this be the New Blood Thinner},
journal = {Clinical Medicine Research},
volume = {3},
number = {5},
pages = {145-149},
doi = {10.11648/j.cmr.20140305.17},
url = {https://doi.org/10.11648/j.cmr.20140305.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140305.17},
abstract = {Background: The effect of capsaicin (the active ingredient in Capsicum frutescensLinn. [Solanaceae] on coagulationwas reported in several studies. Current research is being directed at elucidating if capsaicin has any effect on coagulation. Objectives: To investigate if either the ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) or capsaicin (FlukaBiotechnika-CPF) on coagulation. Methodss: The effects of ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) and capsaicin (FlukaBiotechnika-CPF) was examined on rat hind paw Ten animals in each of three treatment groups received 2.5, 5.0, 10 mg/kg (i.p.) capsaicin respectively. Data obtained were pooled and analysed using repeated ANOVA, in a general linear model with the CPSS software. Results: Compared to the control group, the mean INR was statistically significant (P<0.05). Conclusion: Taken together, the use of capsaicin at therapeutic doses (2.5-10.0 mg/kg) may reduce thromboembolism without any clinically relevant alteration in platelets.},
year = {2014}
}
TY - JOUR T1 - Effects of Capsaicin on Coagulation: Will this be the New Blood Thinner AU - Jolayemi Adebayo Taiwo Ezekiel AU - Ojewole John Akanni Oluwole Y1 - 2014/09/30 PY - 2014 N1 - https://doi.org/10.11648/j.cmr.20140305.17 DO - 10.11648/j.cmr.20140305.17 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 145 EP - 149 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20140305.17 AB - Background: The effect of capsaicin (the active ingredient in Capsicum frutescensLinn. [Solanaceae] on coagulationwas reported in several studies. Current research is being directed at elucidating if capsaicin has any effect on coagulation. Objectives: To investigate if either the ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) or capsaicin (FlukaBiotechnika-CPF) on coagulation. Methodss: The effects of ethyl acetate extract of Capsicum frutescensLinn. [Solanaceae] (CFE) and capsaicin (FlukaBiotechnika-CPF) was examined on rat hind paw Ten animals in each of three treatment groups received 2.5, 5.0, 10 mg/kg (i.p.) capsaicin respectively. Data obtained were pooled and analysed using repeated ANOVA, in a general linear model with the CPSS software. Results: Compared to the control group, the mean INR was statistically significant (P<0.05). Conclusion: Taken together, the use of capsaicin at therapeutic doses (2.5-10.0 mg/kg) may reduce thromboembolism without any clinically relevant alteration in platelets. VL - 3 IS - 5 ER -
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