Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial

Mahfuzur Rahman Babul; Hassanuzzaman; Zaman Ahammed; Anwarul Kibria; Golam Faruk; Akramul Azam; Mizanur Rahman

doi:doi:10.11648/j.ajpn.20170503.11

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Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial

Mahfuzur Rahman Babul, Hassanuzzaman, Zaman Ahammed, Anwarul Kibria, Golam Faruk, Akramul Azam, Mizanur Rahman

Published in American Journal of Psychiatry and Neuroscience (Volume 5, Issue 3)

Received: 3 April 2017 Accepted: 19 April 2017 Published: 31 May 2017

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Abstract

Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.

Published in	American Journal of Psychiatry and Neuroscience (Volume 5, Issue 3)
DOI	10.11648/j.ajpn.20170503.11
Page(s)	31-36
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Fluoxetine, Ischaemic Stroke, Rivermead Mobility Index (RMI), NNT: Number Needed to Treat

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APA Style

Mahfuzur Rahman Babul, Hassanuzzaman, Zaman Ahammed, Anwarul Kibria, Golam Faruk, et al. (2017). Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. American Journal of Psychiatry and Neuroscience, 5(3), 31-36. https://doi.org/10.11648/j.ajpn.20170503.11

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ACS Style

Mahfuzur Rahman Babul; Hassanuzzaman; Zaman Ahammed; Anwarul Kibria; Golam Faruk, et al. Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Am. J. Psychiatry Neurosci. 2017, 5(3), 31-36. doi: 10.11648/j.ajpn.20170503.11

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AMA Style

Mahfuzur Rahman Babul, Hassanuzzaman, Zaman Ahammed, Anwarul Kibria, Golam Faruk, et al. Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Am J Psychiatry Neurosci. 2017;5(3):31-36. doi: 10.11648/j.ajpn.20170503.11

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@article{10.11648/j.ajpn.20170503.11,
  author = {Mahfuzur Rahman Babul and Hassanuzzaman and Zaman Ahammed and Anwarul Kibria and Golam Faruk and Akramul Azam and Mizanur Rahman},
  title = {Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {5},
  number = {3},
  pages = {31-36},
  doi = {10.11648/j.ajpn.20170503.11},
  url = {https://doi.org/10.11648/j.ajpn.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20170503.11},
  abstract = {Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.},
 year = {2017}
}

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TY  - JOUR
T1  - Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial
AU  - Mahfuzur Rahman Babul
AU  - Hassanuzzaman
AU  - Zaman Ahammed
AU  - Anwarul Kibria
AU  - Golam Faruk
AU  - Akramul Azam
AU  - Mizanur Rahman
Y1  - 2017/05/31
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpn.20170503.11
DO  - 10.11648/j.ajpn.20170503.11
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 31
EP  - 36
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20170503.11
AB  - Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.
VL  - 5
IS  - 3
ER  -

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Author Information

Mahfuzur Rahman Babul

Medical Assistant Training School, Noakhali, Bangladesh
Hassanuzzaman

Department of Neurology, Chittagong Medical College Hospital, Chittagong, Bangladesh
Zaman Ahammed

Department of Neurology, Chittagong Medical College Hospital, Chittagong, Bangladesh
Anwarul Kibria

Department of Anatomy, Chittagong Medical College, Chittagong, Bangladesh
Golam Faruk

Department of Anatomy, Chittagong Medical College, Chittagong, Bangladesh
Akramul Azam

Department of Pharmacology, Rangamati Medical College, Chittagong, Bangladesh
Mizanur Rahman

Department of Biochemistry, Rangamati Medical College, Chittagong, Bangladesh

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APA Style

Mahfuzur Rahman Babul, Hassanuzzaman, Zaman Ahammed, Anwarul Kibria, Golam Faruk, et al. (2017). Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. American Journal of Psychiatry and Neuroscience, 5(3), 31-36. https://doi.org/10.11648/j.ajpn.20170503.11

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ACS Style

Mahfuzur Rahman Babul; Hassanuzzaman; Zaman Ahammed; Anwarul Kibria; Golam Faruk, et al. Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Am. J. Psychiatry Neurosci. 2017, 5(3), 31-36. doi: 10.11648/j.ajpn.20170503.11

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AMA Style

Mahfuzur Rahman Babul, Hassanuzzaman, Zaman Ahammed, Anwarul Kibria, Golam Faruk, et al. Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. Am J Psychiatry Neurosci. 2017;5(3):31-36. doi: 10.11648/j.ajpn.20170503.11

Copy | Download

@article{10.11648/j.ajpn.20170503.11,
  author = {Mahfuzur Rahman Babul and Hassanuzzaman and Zaman Ahammed and Anwarul Kibria and Golam Faruk and Akramul Azam and Mizanur Rahman},
  title = {Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {5},
  number = {3},
  pages = {31-36},
  doi = {10.11648/j.ajpn.20170503.11},
  url = {https://doi.org/10.11648/j.ajpn.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20170503.11},
  abstract = {Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial
AU  - Mahfuzur Rahman Babul
AU  - Hassanuzzaman
AU  - Zaman Ahammed
AU  - Anwarul Kibria
AU  - Golam Faruk
AU  - Akramul Azam
AU  - Mizanur Rahman
Y1  - 2017/05/31
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpn.20170503.11
DO  - 10.11648/j.ajpn.20170503.11
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 31
EP  - 36
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20170503.11
AB  - Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.
VL  - 5
IS  - 3
ER  -

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