A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency

Mani B. Monajemi; Seyyed Mohammad Moosavi

doi:doi:10.11648/j.ajpn.20160406.11

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A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency

Mani B. Monajemi, Seyyed Mohammad Moosavi

Published in American Journal of Psychiatry and Neuroscience (Volume 4, Issue 6)

Received: 19 September 2016 Accepted: 9 February 2017 Published: 9 March 2017

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Abstract

Background: Clonidine is α^² adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7^th and 14^th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.

Published in	American Journal of Psychiatry and Neuroscience (Volume 4, Issue 6)
DOI	10.11648/j.ajpn.20160406.11
Page(s)	87-90
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Clonidine, Drug Dependency, Withdrawal Syndrome

References

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Mani B. Monajemi, Seyyed Mohammad Moosavi. (2017). A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. American Journal of Psychiatry and Neuroscience, 4(6), 87-90. https://doi.org/10.11648/j.ajpn.20160406.11

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Mani B. Monajemi; Seyyed Mohammad Moosavi. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. Am. J. Psychiatry Neurosci. 2017, 4(6), 87-90. doi: 10.11648/j.ajpn.20160406.11

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AMA Style

Mani B. Monajemi, Seyyed Mohammad Moosavi. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. Am J Psychiatry Neurosci. 2017;4(6):87-90. doi: 10.11648/j.ajpn.20160406.11

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@article{10.11648/j.ajpn.20160406.11,
  author = {Mani B. Monajemi and Seyyed Mohammad Moosavi},
  title = {A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {4},
  number = {6},
  pages = {87-90},
  doi = {10.11648/j.ajpn.20160406.11},
  url = {https://doi.org/10.11648/j.ajpn.20160406.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20160406.11},
  abstract = {Background: Clonidine is α² adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7th and 14th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.},
 year = {2017}
}

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TY - JOUR
T1 - A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency
AU - Mani B. Monajemi
AU - Seyyed Mohammad Moosavi
Y1 - 2017/03/09
PY - 2017
N1 - https://doi.org/10.11648/j.ajpn.20160406.11
DO - 10.11648/j.ajpn.20160406.11
T2 - American Journal of Psychiatry and Neuroscience
JF - American Journal of Psychiatry and Neuroscience
JO - American Journal of Psychiatry and Neuroscience
SP - 87
EP - 90
PB - Science Publishing Group
SN - 2330-426X
UR - https://doi.org/10.11648/j.ajpn.20160406.11
AB - Background: Clonidine is α² adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7th and 14th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.
VL - 4
IS - 6
ER -

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Author Information

Mani B. Monajemi

Department of Psychology, University of Tehran, Tehran, Iran
Seyyed Mohammad Moosavi

Department of Psychiatry, Psychiatry and Behavioral Science Research Center, Mazandaran University of Medical Sciences, Sari, Iran

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APA Style

Mani B. Monajemi, Seyyed Mohammad Moosavi. (2017). A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. American Journal of Psychiatry and Neuroscience, 4(6), 87-90. https://doi.org/10.11648/j.ajpn.20160406.11

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ACS Style

Mani B. Monajemi; Seyyed Mohammad Moosavi. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. Am. J. Psychiatry Neurosci. 2017, 4(6), 87-90. doi: 10.11648/j.ajpn.20160406.11

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AMA Style

Mani B. Monajemi, Seyyed Mohammad Moosavi. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency. Am J Psychiatry Neurosci. 2017;4(6):87-90. doi: 10.11648/j.ajpn.20160406.11

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@article{10.11648/j.ajpn.20160406.11,
  author = {Mani B. Monajemi and Seyyed Mohammad Moosavi},
  title = {A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {4},
  number = {6},
  pages = {87-90},
  doi = {10.11648/j.ajpn.20160406.11},
  url = {https://doi.org/10.11648/j.ajpn.20160406.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20160406.11},
  abstract = {Background: Clonidine is α² adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7th and 14th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.},
 year = {2017}
}

Copy | Download