Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice

Marowa Mansour AlMathkour; Entissar Suliman AlSuhaibani

doi:doi:10.11648/j.ajls.20140204.13

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Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice

Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani

Published in American Journal of Life Sciences (Volume 2, Issue 4)

Received: 4 August 2014 Accepted: 11 August 2014 Published: 20 August 2014

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Abstract

This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.

Published in	American Journal of Life Sciences (Volume 2, Issue 4)
DOI	10.11648/j.ajls.20140204.13
Page(s)	205-210
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Aspirin, Sperm Malformation, Radioprotection

References

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APA Style

Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. (2014). Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. American Journal of Life Sciences, 2(4), 205-210. https://doi.org/10.11648/j.ajls.20140204.13

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ACS Style

Marowa Mansour AlMathkour; Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am. J. Life Sci. 2014, 2(4), 205-210. doi: 10.11648/j.ajls.20140204.13

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AMA Style

Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am J Life Sci. 2014;2(4):205-210. doi: 10.11648/j.ajls.20140204.13

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@article{10.11648/j.ajls.20140204.13,
  author = {Marowa Mansour AlMathkour and Entissar Suliman AlSuhaibani},
  title = {Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {4},
  pages = {205-210},
  doi = {10.11648/j.ajls.20140204.13},
  url = {https://doi.org/10.11648/j.ajls.20140204.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140204.13},
  abstract = {This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.},
 year = {2014}
}

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TY  - JOUR
T1  - Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice
AU  - Marowa Mansour AlMathkour
AU  - Entissar Suliman AlSuhaibani
Y1  - 2014/08/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140204.13
DO  - 10.11648/j.ajls.20140204.13
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 205
EP  - 210
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140204.13
AB  - This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
VL  - 2
IS  - 4
ER  -

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Author Information

Marowa Mansour AlMathkour

College of Science, King Saud University, Riyadh, Saudi Arabia
Entissar Suliman AlSuhaibani

College of Science, King Saud University, Riyadh, Saudi Arabia

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APA Style

Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. (2014). Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. American Journal of Life Sciences, 2(4), 205-210. https://doi.org/10.11648/j.ajls.20140204.13

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ACS Style

Marowa Mansour AlMathkour; Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am. J. Life Sci. 2014, 2(4), 205-210. doi: 10.11648/j.ajls.20140204.13

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AMA Style

Marowa Mansour AlMathkour, Entissar Suliman AlSuhaibani. Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice. Am J Life Sci. 2014;2(4):205-210. doi: 10.11648/j.ajls.20140204.13

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@article{10.11648/j.ajls.20140204.13,
  author = {Marowa Mansour AlMathkour and Entissar Suliman AlSuhaibani},
  title = {Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {4},
  pages = {205-210},
  doi = {10.11648/j.ajls.20140204.13},
  url = {https://doi.org/10.11648/j.ajls.20140204.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140204.13},
  abstract = {This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Protective Effect of Aspirin on γ Radiation-Induced Sperm Malformations in Swiss Albino Male Mice
AU  - Marowa Mansour AlMathkour
AU  - Entissar Suliman AlSuhaibani
Y1  - 2014/08/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140204.13
DO  - 10.11648/j.ajls.20140204.13
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 205
EP  - 210
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140204.13
AB  - This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less, mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy). The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiation-treated mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
VL  - 2
IS  - 4
ER  -

Copy | Download